Year: 2025
Type: article
Study design: Case Report
Abstract: Glucagonoma is a rare pancreatic alpha-cell tumor that leads to glucagonoma syndrome, typically characterized by necrolytic migratory erythema (NME), diabetes, weight loss, and anemia. We present the case of a 47-year-old man with a one-year history of diabetes and a relapsing pustular and scaly dermatosis. Examination revealed widespread annular erythematous plaques. Laboratory tests showed anemia, hypoalbuminemia, and hyperglycemia. Skin biopsy demonstrated epidermal necrolysis, and abdominal imaging identified a 3.1 cm tumor in the pancreatic tail. Surgical resection confirmed a well-differentiated neuroendocrine tumor (Ki67: 1%), and skin lesions resolved postoperatively. This case highlights an atypical presentation of NME and the importance of early recognition to reduce diagnostic delay in glucagonoma syndrome.
Source: Cureus
DOI: 10.7759/cureus.99747
Author: Hiebda Sofía Martínez Jiménez
Institution: Centro Medico Nacional Siglo XXI
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417530791