Work

GPER1 activation regulates renal purinergic P2Y 2 receptor natriuretic pathway

Year: 2025

Type: article

Abstract: Systemic GPER1 activation upregulated renal Cx30 and P2Y 2 receptor mRNA expression in ovariectomized rats, whereas genetic deletion of GPER1 downregulated renal Cx30 and P2Y 2 receptor mRNA expression in ovary-intact female mice. Acute renal medullary GPER1 activation enhances natriuresis and urinary ATP excretion in ovary-intact female rats. These findings indicate that GPER1 regulates the natriuretic Cx30/ATP/P2Y 2 receptor signaling pathway in the kidney, which may contribute to the blood pressure-lowering response to GPER1 activation.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00123.2025

Authors: Supaporn Kulthinee, Victoria L. Nasci, David M. Pollock, Eman Y. Gohar

Institutions: Vanderbilt University Medical Center, University of Alabama at Birmingham

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases