Year: 2025
Type: article
Study design: Observational Study
Abstract: Thyroid dysfunction is a common health disorder. However, data on its incidence remain scarce and geographically limited. This study aimed to assess the incidence of thyroid dysfunction in the Spanish adult population and factors associated with its onset. A nationwide observational population‑based cohort study was conducted, including 1,629 euthyroid individuals (not receiving levothyroxine/thionamides, and TSH levels of 0.2-5.0mIU/mL) at baseline (2008-2010), who were re-evaluated in 2016-2017. Multivariable logistic regression analysis assessed the association between incident thyroid dysfunction and potential exposure factors. ROC analysis identified optimal TPOAb and TSH cut-offs for predicting incident hypothyroidism. The age- and sex-adjusted incidence of hypothyroidism was 13.38cases/1,000persons-year (CI95% 10.52-16.25) for TSH ≥ 5mIU/mL, and 6.78cases/1,000persons-year (CI95% 4.73-8.83) for TSH ≥ 10mIU/mL. The incidence of hyperthyroidism was 2.65cases/1,000persons-year (CI95% 1.46-3.83). Female sex, age between 30 and 40 and > 60 years, TPOAb > 20mIU/L and TSH > 2.8mIU/mL were independently associated with new cases of hypothyroidism. The presence of obesity, diabetes or urinary iodine levels were not associated with the incidence of thyroid disease. Baseline TPOAb and TSH cut-offs best predicting hypothyroidism were 9.1mIU/L (AUC 0.654; CI95% 0.583-0.725; p < 0.001), and 2.03mIU/mL (AUC 0.702; CI95% 0.639-0.766; p < 0.001) respectively. This study provides data on incidence rates and risk factors of thyroid dysfunction in the adult Spanish population.
Source: Scientific Reports
Authors: Silvia Patricia Alonso, Natalia Colomo, Ana Lago-Sampedro, Cristina Maldonado-Araque, Eduardo García-Fuentes, Carolina Gutiérrez-Repiso, María José Tapia-Guerrero, Inmaculada Rueda, Pilar Ocón Sánchez, Wasima Oualla-Bachiri, Alfonso Calle-Pascual, Luis Castaño, Elías Delgado-Álvarez, Edelmiro Menéndez-Torre, Josep Franch-Nadal, Inés Urrutia, Juan Girbés, Felipe Javier Chaves, Eduard Montanya, Gemma Rojo-Martínez, Sergio Valdés
Institutions: Hospital Costa del Sol, Universidad de Málaga, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Hospital Regional Universitario de Málaga, Centro de Investigación Biomédica en Red, Andalusian Centre for Nanomedicine and Biotechnology, Instituto de Investigación Biomédica de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Hospital Clínico Universitario Virgen de la Victoria, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, University of the Basque Country, Centre for Biomedical Network Research on Rare Diseases, Hospital de Cruces, Universidad de Oviedo, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Institut Universitari d'Investigació en Atenció Primària Jordi Gol, Institut Català de la Salut, Hospital Arnau de Vilanova, INCLIVA Health Research Institute, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, Universitat de Barcelona
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: Valor predictivo de los miRNA séricos en el desarrollo de enfermedades metabólicas y su relación con el grado de exposición a partículas y otros contaminantes del aire, Estado de nutrición de selenio en la población española. Relación con la prevalencia e Incidencia de enfermedad tiroidea y diabetes tipo 2. Estudio [email protected], G781323451, Polución del aire y riesgo de diabetes en población adulta Española. Efecto mediador de los miRNA. Estudio [email protected], G8735638945
OpenAlex ID: W4417534912