Work

PFOS-induced black liver and hepatic aging in mice: A new paradigm in environmental hepatotoxicology

Year: 2025

Type: article

Abstract: ), and sirtuin reduction (SIRT1 and SIRT7). Mechanistically, chronic PFOS downregulated autophagy complexes (ULK1-FIP200-ATG13 and ATG14L-Beclin1-Vps34) and reduced LC3B-I/II conversion, indicating impaired autophagosome formation and blocked flux. Pharmacological restoration of autophagy in PFOS-treated AML12 cells ameliorated intracellular lipid droplets, canalicular disruption, oxidative stress and aging pigment buildup, suggesting PFOS as a silent driver of irreversible liver aging at least through autophagy suppression. Finally, transcriptomics of PFOS-exposed human liver spheroids recapitulated aging and cholestasis, underscoring translational relevance. These findings redefine the occupational toxicological profile of PFOS, supporting the inclusion of congestion, pigment, and aging biomarkers in occupational PFAS assessments.

Source: Environment International

DOI: 10.1016/j.envint.2025.109999

Authors: Camille K. Stevenson, Jiang Wang, Chunying Du

Institution: University of Cincinnati

Language: English

Topic: Per- and polyfluoroalkyl substances research

Subfield: Environmental Chemistry

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,750