Hyperglycemia Increased The Expression of CALCRL G Protein-Coupled Receptor in Monocytes from Diabetic Patients.
Year: 2025
Type: article
Abstract: Objective: Diabetes is a metabolic disorder with two common categories of complications: microvascular and macrovascular. Cardiovascular diseases (CVDs), which are linked to inflammation in the blood vessels, are the most important complications of diabetes. G protein-coupled receptors (GPCRs) play a crucial role in initiating these inflammatory responses. The aim of this study is to identify GPCRs that may respond to high blood glucose in monocyte cells and have an effect on regulating vascular inflammation. Materials and Methods: expression, generation of reactive oxygen species (ROS), and caspase activity was evaluated. Results: expression, ROS production, and caspase 3/7 activity. Conclusion: GPCR in the monocytes of diabetic patients. The CALCRL receptor may play a key role in regulating vascular inflammation in hyperglycemic conditions. Targeting CALCRL may control inflammation in blood cells.
Source: PubMed
Authors: Seyedeh Zohreh Azarshin, Maral Marashi, Zahra Abedi Kichi, Mohammad Ali Boroumand, Mehrdad Behmanesh
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4417535336
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