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Synthetic methods for key precursors of biologically active dimethylsulfoxide ruthenium complexes

Year: 2025

Type: article

Abstract: Microwave- and sonication-assisted methods provide efficient synthesis of octahedral Ru(II) and Ru(III) S- and O-bound dimethyl sulfoxide (DMSO) complexes, precursors to anticancer, antimicrobial and anti-neurodegenerative drugs, in comparison with conventional hotplate (thermal) synthesis. In addition, sonication led to a novel O-bound DMSO oxo-bridged di-Ru(IV) complex, for which the X-ray structure, solvolysis, reduction by ferrocene, and Density Functional Theory (DFT) calculations are reported.

Source: Dalton Transactions

DOI: 10.1039/d5dt02617b

Authors: Sreshtha Nayek, Rodrigo S. Correa, Ehsan Ezzatpour Ghadim, Juliusz A. Wolny, Volker Schünemann, Rafael Cavalieri Marchi, Peter J. Sadler

Institutions: University of Warwick, Universidade Federal de Ouro Preto, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: University of Warwick, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Engineering and Physical Sciences Research Council

Awards: G2059633422, EPRSC Resource Only Strategic Equipment: the Warwick Analytical Science Centre, PLATAFORMA DE ENSAIOS BIOLÓGICOS PARA COMPOSTOS DE COORDENAÇÃO A BASE DE RUTÊNIO: UMA ALTERNATIVA PARA QUIMIOTERAPIA CONTRA O CÂNCER E DOENÇAS NEGLIGENCIADAS., G5686940158, Warwick Centre for Analytical Science, G6495596797, G819737741, G987229451

OpenAlex ID: W4417535533

FWCI:

Cites: 63

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