The role of plant-derived compounds in anti-obesity drug discovery: A molecular perspective
Year: 2025
Type: review
Abstract: Obesity is a complex and multifaceted disease associated with metabolic diseases and severe health problems worldwide. There is an urgent need for novel therapeutic strategies since the currently available treatment options are often ineffective or cause adverse effects. Since they can modulate crucial biochemical pathways,phytochemicals, which are plant-derived compounds, provide a promising approach to the design of anti-obesity drugs. Such ways through which these substances work are preventing adipogenesis, regulating lipid metabolism, dropping inflammation, improving insulin sensitivity, and reestablishing energy balance. These are some of the main topics of this review. Numerous phytochemicals have emerged as auspicious agents targeting adipocytes, gut bacteria, and essential enzymes elaborate in metabolic pathways associated to obesity, such as polyphenols, flavonoids, and terpenes. Additional preclinical and clinical data testify to the rationality of these molecules toward their intended therapy aims. Prospects for incorporating phytochemicals into treatment plans for obesity are deliberated next, along with potential synergistic effects of plant bioactives and allegations for polyherbal formulations.
Source: Current Opinion in Pharmacology
Authors: Vetriselvan Subramaniyan, Ram Narayanan Ravi, Sammra Maqsood, Sachin Kumar Singh, Vellapandian Chitra, Kamal Dua, Brian G. Oliver, Sivaraman Dhanasekaran, Gaurav Gupta, Thakur Gurjeet Singh
Institutions: Dr. D.Y. Patil Vidyapeeth, Pune, Dr D Y Patil Dental College & Hospital, Malla Reddy Vishwavidyapeeth, Karpagam Academy of Higher Education, Sunway University, Monash University Malaysia, University of Agriculture Faisalabad, Lovely Professional University, SRM Institute of Science and Technology, University of Technology Sydney, Pandit Deendayal Energy University, Chitkara University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,510
OpenAlex ID: W4417535586