Allergic comorbidities among inborn errors of immunity in children attended in a high-complexity center in Cali, Colombia
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To describe the clinical characteristics of allergic diseases (AD) as comorbidities-distinct from primary atopic diseases (PAD)-in pediatric patients diagnosed with IEI. METHODS: An observational and retrospective study was made. We included pediatric population diagnosed with IEI and allergic comorbidity between 2013-2023. The diagnosis was done considering the criteria from the ESID and IUIS-2022. We performed a descriptive analysis of the variables (frequencies/percentages). For qualitative variables, we used OR to obtain the probability of occurrence of allergic sensitization among patients with AD and IEI. Every analysis was performed with the software R Studio version 3.2.2. RESULTS: There were 366 patients with diagnosis of IEI, 238 had concomitant AD. 59.6% were males. Mean age was 5 years. 84% had antibody-specific deficiencies, 8% combined immunodeficiencies associated to well-defined syndromes, 2.9% congenital defects in phagocytes, 2.5% combined-immunodeficiencies, 1.7% autoinflammatory diseases, and 0.8% defects in intrinsic and innate immunity. The distribution of the ADs was asthma 48.7%, rhinitis 18.9%, atopic-dermatitis 15.1%, food-allergy 8.4%, acute urticaria 5%, and chronic urticaria 3.8%. CONCLUSION: Allergic diseases are increasingly recognized as key indicators for early IEI diagnosis. These conditions may coexist without representing PAD, emphasizing the need for comprehensive care. Recognizing this heterogeneity supports a multidisciplinary approach to improve early detection and management of IEI.
Source: Revista Alergia México
Authors: Jacobo Triviño Arias, Sofía Martinez Betancur, Oriana Arias Valderrama, Tania Marcela Guzman, Juan Pablo Diaz Solórsano, Diego Medina, Alexis Franco, Jaime Patiño, Paola Marsela Pérez, Harry Mauricio Pachajoa, Manuela Olaya Hernandez
Institution: Fundación Valle del Lili
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $300
OpenAlex ID: W4417535627