Work

Chronic Thromboembolic Pulmonary Hypertension Incidence, Post-pulmonary Embolism Syndrome and Possible Role of Transcatheter Therapy in Prevention

Year: 2025

Type: article

Abstract: Pulmonary embolism (PE) presents both acute and chronic complications that significantly affect patient outcomes. Acute complications include syncope or sudden death, often resulting from severe hypoxaemia or right ventricular failure; and early recurrence of the embolic event. Chronic complications, which can develop over time, are often grouped under post-embolic syndrome (PES), a condition affecting more than half of PE survivors. Symptoms of PES include persistent dyspnoea and reduced exercise tolerance. PES is associated with several serious conditions, such as chronic thromboembolic pulmonary hypertension, chronic thromboembolic pulmonary disease, right ventricular dysfunction, physical deconditioning, and psychological harm. Although promising catheter-directed therapies are under investigation for acute PE treatment, their effectiveness in preventing chronic complications has yet to be confirmed by large-scale randomised controlled trials.

Source: Interventional Cardiology Reviews Research Resources

DOI: 10.15420/icr.2024.50

Authors: Belén Biscotti Rodil, Juan Duarte Torres, Irene Martín de Miguel, Alejandro Cruz Utrilla, Nicolás Maneiro Melón, Jorge Nuche Berenguer, Yolanda Revilla Ostolaza, Sergio Alonso Charterina, María Jesús López Gude, Carmen Jiménez López-Guarch, Fernando Arribas Ynsaurriaga, Pilar Escribano Subías, Maite Velázquez Martín

Institution: Hospital Universitario 12 De Octubre

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,146

Funders: Pfizer, AOP Orphan, Instituto de Salud Carlos III

Awards: G2114388608, G6652501457

OpenAlex ID: W4417535979