The role of dietary factors in the prevention and management of inflammatory bowel disease: a comprehensive review
Year: 2025
Type: article
Abstract: Crohn’s disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), are chronic conditions characterized by relapsing inflammation in the gastrointestinal tract. Although the etiology of IBD remains unclear, it is now well-established that both genetic susceptibility and environmental factors including diet, play essential roles in its pathogenesis. Dietary components can influence gut microbiota composition, immune regulation, and intestinal barrier integrity, thereby modulating disease onset, severity, and relapse. While some nutritional patterns and specific nutrients show therapeutic potential, others may aggravate inflammation. This comprehensive review explores the influence of macronutrients, micronutrients, and dietary regimens such as the Mediterranean diet, low FODMAP, and exclusive enteral nutrition on IBD. Additionally, the review highlights current evidence, clinical relevance, and research gaps in using dietary strategies to prevent and manage IBD effectively.
Source: Nutrition & Metabolism
Authors: Elyas Nattagh-Eshtivani, Hanieh Barghchi, Amir Hossein Mansouri, Pegah Rahbarinejad, Amin Mokari-Yamchi, Mehdi Barati, Mohammad Rashidmyvan, Ali Jafazadeh Esfehani, Alireza Mohammadzadeh, Zachry Clyton, Parisa Marabi, Saeedeh Talebi, Naseh Pahlavani
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,590
OpenAlex ID: W4417537235