Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin.
Year: 1992
Type: article
Abstract: THE immunosuppressive properties of FK 506 have been documented in many studies both in vitro and in vivo.1 Ideal immunosuppression of solid organ transplantation would produce immunologic suppression of the allograft recipient without adverse toxic effects. Decreasing the dose of FK 506 to the lowest effective level will minimize its side effects. This study attempts to elucidate the relationship between low doses of FK 506 and the corresponding blood value, and graft survival after treatment cessation in allotransplantation of liver, heart, and skin in rat models.
Source: PubMed
Authors: X Cai, J Harnaha, P N Rao, J Flowers, R Venkataramanan, V Warty, J J Fung, T E Starzl
Institution: University of Pittsburgh
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W45963869