Cellular and molecular strategies to overcome macrophage-mediated axonal dieback after spinal cord injury
Year: 2009
Type: article
Abstract: Dystrophic growth cones retract extensively after contact with macrophages in an in vitro model of the glial scar Macrophages express and secrete MMP-9 Broad spectrum inhibition of matrix metalloproteinases prevents macrophage-mediated axonal retraction Inhibition of MMP-9, but not MMP-2, prevents macrophagemediated retraction of dystrophic axons Digestion of proteoglycan with Chondroitinase ABC prevents axonal retraction Embryonic neurons are resistant to macrophage attack in vitro Preconditioning adult neurons reduces macrophagemediated axonal retraction A conditioning lesion prevents axonal dieback in vivo Discussion Figures 4-17 CHAPTER III -Adult NG2+ progenitor cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury
Author: Sarah A. Busch
Institution: Case Western Reserve University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W46433288