Work

Microencapsulation of Pancreatic Islets for Use in a Bioartificial Pancreas

Year: 2013

Type: book-chapter

Abstract: Islet transplantation is the most exciting treatment option for individuals afflicted with Type 1 diabetes. However, the severe shortage of human pancreas and the need to use risky immunosuppressive drugs to prevent transplant rejection remain two major obstacles for the routine use of islet transplantation in diabetic patients. Successful development of a bioartificial pancreas using the approach of microencapsulation with perm-selective coating of islets with biopolymers for graft immunoisolation holds tremendous promise for diabetic patients because it has great potential to overcome these two barriers. In this chapter, we provide a detailed description of the microencapsulation process.

Source: Methods in molecular biology

DOI: 10.1007/978-1-62703-363-3_21

Authors: Emmanuel C. Opara, John P. McQuilling, Alan C. Farney

Institutions: Wake Forest University Health Sciences, Wake Forest University, Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences, Virginia Tech

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering