Work

Effect of trifluoperazine on carrageenan-induced acute inflammation in intact and adrenalectomized rats.

Year: 2009

Type: article

Abstract: The aim of present study was to investigate the effect of trifluoperazine (TFP) on carrageenan-induced rat's paw edema in intact and adrenalectomized (ADX). TFP (0.2 and 8 mg/kg) were given intraperitoneally just before the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes and extravasations of Evans blue dye as inflammatory indicators. In both ADX and control groups, administration of TFP reduced inflammatory parameters (paw volume and tissue content of Evans blue dye) in inflamed paw. Our findings suggest that TFP can effectively reduce carrageenan-induced paw edema in both ADX and control rats. Therefore, anti-inflammatory effect of these drugs does not need the adrenal gland activity.

Source: PubMed Central

Authors: Mehdi Mahmoodi, Mohammad Khaksari Hadad, Ali Shamsizadeh, Afrooz Azarang, Reza Abbasi Rayeni

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W47344280

FWCI: 0.235

Cites: 13

Cited by: 7

Related to: 10