Year: 1989
Type: article
Abstract: IVER TRANSPLANT patients require chronic admin- istration of immunosuppressive agents to prevent the rejection of transplanted organs.Such therapy usually includes low-dose steroids (prednisone) in combination with cyclosporine. 1 The exact dose of prednisone used is e~pir~ cally determined and must be balanced between that which IS sufficient to maintain graft survival and that which causes minimal side effects.Since the availability and duration of unbound steroid at the receptor site is a determining factor for the time course of its pharmacologic action, a thorough understanding of the pharmacokinetic parameters, such as the rate and extent of absorption, protein binding, tissue distribution, biotransformation, and excretion, is very important.2 Very little information is available on the pharmacokinetics of prednisone or prednisolone in liver transplant patients.The objective of the present study is to characte~ize the pharmacokinetics of prednisolone in clinically sta ble hver transplant patients.
Source: PubMed
Institution: University of Pittsburgh
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W47584891