Transparent Window Models and Intravital Microscopy
Year: 2002
Type: book-chapter
Abstract: The past 30 years have witnessed spectacular advances in our understanding of the molecular origins of cancer and other diseases. These advances have led to the identification of various genes associated with angiogenesis and oncogenesis, and to the development of a vast array of therapeutic agents. The grand challenges now are to relate the expression of these genes to their function in an intact organism, and to deliver these novel therapeutics to their targets in vivo (70). Currently, gene expression, physiological function, and drug delivery are usually measured with techniques that are either destructive or have poor spatial resolution (millimeter to centimeter). The former have limited ability to provide insight into the dynamics, and the latter preclude visualization at the cellular and subcellular levels (1–10 µm).
Source: Humana Press eBooks
Authors: Rakesh K. Jain, Lance L. Munn, Dai Fukumura
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4908954