Role of Locally Synthesised Protein in Long Term Memory - An Analytical Approach
Year: 2014
Type: article
Abstract: Permanent alteration in the structure and number of synapses involves new protein synthesis and assemblage of new memory circuits resulting changes in electrical activity of specific regions of the brain due to different learning experiences. Injections of protein inhibitor in the temporal lobe of mice led to the fact that learning is effective in long-term memory (LTM). Studies of long term potentiation (LTP) and long term depression (LTD) in mammalian brains resulted in two distinct phases- the early one (typically lasting 1-3 hours) is independent of new protein synthesis and the late one (typically lasting more than 8 hours) depends on new protein synthesis. This paper focuses on developing an Analytical Approach for mathematical analysis of these experimental findings basing on the role of protein vibrations in learning and memory with the assumption that dissociation or association of the number of amino acid molecules are required for synthesis of new protein responsible for LTM.
Authors: Brajagopal Majumder, Former
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4945531