Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids.
Year: 1974
Type: article
Abstract: Elevated levels of blood cholesterol and triglyceride are recognized risk factors for coronary atherosclerosis [1-4]. It is not yet known whether lowering the level of elevated blood lipids will prevent or retard the onset of coronary heart disease, but if such treatment is to be effective, it should probably be started as early as possible-that is, during childhood. It therefore becomes important to establish the diagnosis of hyperlipidemia at the earliest age. Glueck and co-workers [5] have suggested that measurement of umbilical cord blood cholesterol levels in consecutively studied healthy babies can be used as a population screening test for the diagnosis of one genetic lipid disorder, familial hypercholesterolemia. These data have been challenged by Darmady et al. [6], who claim that cord blood cholesterol levels do not accurately reflect the blood cholesterol levels of the same infants at 1 year of age and hence cannot be used as a reliable index of familial hypercholesterolemia. However, Kwiterovich and co-
Source: Europe PMC (PubMed Central)
Institution: University of Washington
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W50237377