Tryptophan in the treatment of late luteal phase dysphoric disorder: a pilot study.
Year: 1994
Type: article
Study design: Clinical Trial
Abstract: Thirteen patients diagnosed during two menstrual cycles as suffering from late luteal phase dysphoric disorder were then followed in an open pilot study for a further three cycles. During one complete cycle, baseline levels of symptoms were obtained. During the next three cycles, the patients were treated with L-tryptophan, six grams per day. L-tryptophan treatment was associated with a significant amelioration of symptoms with only mild side effects. These data suggest that L-tryptophan should be tested at a dose of six grams of L-tryptophan per day in a placebo-controlled study in patients with late luteal phase dysphoric disorder who suffer from symptoms such as depression, irritability, insomnia and carbohydrate craving, which may respond to potentiation of serotonin function.
Source: PubMed Central
Authors: S Steinberg, L Annable, S N Young, M C Bélanger
Institution: St Mary's Hospital Centre
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W508831