mRNA and microRNA expression patterns in adrenocortical cancer.
Year: 2011
Type: article
Abstract: Adrenocortical cancer is a rare tumor and its prognosis is poor. Although numerous tumor-associated genetic and signal transduction alterations have been described to date, its pathogenesis is still unclear. Hybridization-based DNA microarray approaches may reveal significant gene expression alterations and may thus contribute to a better understanding of tumorigenesis and may identify molecular markers applicable for the distinction of benign and malignant lesions. Beside gene expression patterns, studies on microRNAs seem to be useful, as well. Novel therapeutical targets might be established by these approaches. In this review, the authors attempt to summarize the main findings of mRNA and microRNA expression microarray studies performed to date in adrenocortical cancer including a recent meta-analysis of gene expression data and present novel pathogenic pathways.
Source: PubMed Central
Authors: Adrienn Zsippai, Diana Rita Szabó, Peter M Szabó, Zsófia Tömböl, Melinda R Bendes, Zoltán Nagy, Károly Rácz, Peter Igaz
Institution: Semmelweis University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W51030972