The inhibition of tyrosinase by pyridinones
Year: 1989
Type: article
Abstract: 3-Hydroxypyridine-4-ones have potential as orally active chelators of iron(III) and therefore may find application in the treatment of thalassaemia. An undesirable feature of these molecules is that they inhibit tyrosinase. We have established that alkyl substitution at position 2 in the aromatic ring minimizes interaction with tyrosinase and does so without appreciably influencing the affinity for iron(III).
Source: Biochemical Journal
DOI: 10.1042/bj2570289
Authors: R C Hider, K Lerch
Institutions: King's College London, University of Zurich
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W51577300