Characterization and prevention of the “small-for-size” syndrome in a porcine model of hepatic transplant
Year: 2011
Type: dissertation
Abstract: The hypothesis of this doctoral thesis is two-fold: 1. Excessive portal vein flow is present immediately after portal reperfusion in the recipient and is the instigating factors in a series of events that ultimately lead to the development of “small-for-size” syndrome (SFSS). 2. A calibrated portocaval shunt prevents postreperfusion portal hyperperfusion and, thereby, the development of SFSS in partial liver grafts. The objectives of this doctoral thesis are as follows: 1. To produce a porcine model of acute SFS injury that does not use venovenous bypass, in order to study the presentation of SFSS and characterize the cellular lesion in relation to altered hepatic hemodynamics. 2. To study the effects of modifying portal vein flow through the creation of portocaval shunts of different sizes, each calibrated to achieve a distinct decrease in the amount of flow ultimately reaching the SFS liver graft. 3. To determine the optimal decrease in the amount of portal vein flow that is capable of preventing the deleterious consequences of portal hyperperfusion and improving postoperative graft function and survival in SFS liver grafts.
Author: Amelia J. Hessheimer
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W54753904