Alcohol Induced Psychotic Disorder: a comparitive study in patients with alcohol dependance, schizophrenia and normal controls
Year: 2007
Type: dissertation
Abstract: Alcohol-induced psychotic disorder (also known as alcohol hallucinosis) is a complication of alcohol abuse that requires clinical differentiation from alcohol withdrawal delirium and schizophrenia.Although extensively described, few studies utilized standardized research instruments and brain-imaging has thus far been limited to case reports.The aim of this study was to prospectively compare four population groups (ie.patients with alcohol-induced psychotic disorder, schizophrenia, uncomplicated alcohol dependence and a healthy volunteer group) according to demographic, psychopathological and brainimaging variables utilizing (i) rating scales and (ii) single photon emission computed tomography (SPECT).The third component of the study was designed to investigate the (iii) effect of anti-psychotic treatment on the psychopathology and regional cerebral blood flow (rCBF) before and after six weeks of treatment with haloperidol.Effort was made to ensure exclusion of comorbid medical disorders, including substance abuse.The study provides further supportive evidence that alcohol-induced psychotic disorder can be distinguished from schizophrenia.Statistically significant differences in rCBF were demonstrated between the alcohol-induced psychotic disorder and other groups.Changes in frontal, temporal, parietal, occipital, thalamic and cerebellar rCBF showed statistically significant negative correlations with post-treatment improvement on psychopathological variables and imply dysfunction of these areas in alcohol-induced psychotic disorder.The study was unable to distinguish between pharmacological effects and improvement acccomplished by abstinence from alcohol.OPSOMMING Alkohol-geïnduseerde psigose (ook bekend as alkohol hallusinose) is 'n komplikasie van alkoholmisbruik wat kliniese onderskeid van alkoholonttrekkings-delirium en skisofrenie benodig.Alhoewel reeds omvattend beskryf, het min studies tot dusver gestandardiseerde navorsing instrumente gebruik en breinbeelding is beperk tot gevallestudies.Die doel van die studie was om vier studiegroepe (nl.pasiënte met alkoholgeïnduseerde psigose, skisofrenie, ongekompliseerde alkoholafhanklikheid en 'n gesonde vrywilliger groep) prospektiewelik volgens demografiese, psigopatologiese en breinbeelding veranderlikes te vergelyk deur van (i) meetskale en (ii) enkel foton emissie rekenaar tomografie ("SPECT") gebruik te maak.Die derde deel van die studie was ontwerp om die (iii) effek van anti-psigotiese behandeling op die psigopatologie en serebrale streekbloedvloei ("rCBF") voor en na ses weke behandeling met haloperidol te ondersoek.Voorsorg was gemaak om uitsluiting van gepaardgaande mediese toestande insluitende substansmisbruik te verseker.Die studie verskaf verdere ondersteunende getuienis dat alkohol-geïnduseerde psigose van skisofrenie onderskei kan word.Statisties betekenisvolle verskille in serebrale streekbloedvloei tussen die alkohol-geïnduseerde psigose en ander groepe was aangetoon.Veranderings in frontale, temporale, pariëtale, oksipitale, talamiese en serebellêre streekbloedvloei het statisties betekenisvolle negatiewe korrelasies met na-behandeling verbetering in psigopatologiese veranderlikes getoon en impliseer disfunksie in hierdie gebiede.Die studie was nie in staat om tussen farmakologiese effekte en beterskap op grond van onthouding van alkohol te onderskei nie.(MW) Key to p values (Bonferroni): Alcohol-induced psychotic disorder vs. Schizophrenia: (a) p<0.01,(b) p>0.05;Alcohol-induced psychotic disorder vs. Alcohol dependence: (c) p<0.01,(d) p>0.05);Alcohol-induced psychotic disorder vs. Healthy volunteers: (e) p<0.01, (f) p>0.05;Schizophrenia vs Alcohol dependence: (g) p<0.01, (
Authors: Gerhard P. Jordaan, Robin Emsley
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W55526410