Work

Delivery of antisense oligonucleotides from photopolymerized hydrogels

Year: 1993

Type: article

Abstract: Antisense oligonucleotides promise to be highly potent therapeutic agents. Nanomolar extracellular concns. of phosphorothioate oligonucleotides have been reported to significantly alter gene expression in cultured cells. (Tidd, 1990). PEG derived hydrogels appear to be appropriate for delivering these concns. or higher for prolonged periods of time, and should protect the antisense oligonucleotides from enzymic degrdn. prior to cellular uptake. Release from these hydrogels follows predictable and alterable kinetics. The addnl. ability to polymerize the oligonucleotide-contg. macromer soln. in situ makes this advancement particularly exciting. [on SciFinder (R)]

Source: Infoscience (Ecole Polytechnique Fédérale de Lausanne)

Authors: J. L. Hill-West, Jeffrey A. Hubbell

Institution: The University of Texas at Austin

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W568004660

FWCI: 0.236

Cites:

Cited by: 1

Related to: 10