Work

Ship1 Deletion Enhances Ros Production and Decreases Survival of the S. Aureus Infected Mice

Year: 2013

Type: article

Abstract: Reactive oxygen species (ROS) production by neutrophils is essential for host innate immune defense. However, although ROS production is advantageous for killing various infectious organisms, excessive ROS can cause tissue damage. Thus, ROS production by neutrophils must be tightly controlled. In this study, we investigated a role for SH2 domain-containing inositol- 5-phosphatase 1 (SHIP1), a PtdIns(3,4,5)P3 phosphatase, in ROS production by neutrophils using ship1−/− mice. SHIP1 deletion enhanced ROS production as well as the bacterial killing capability of neutrophils. However, the ship1−/− mice showed decreases survival of the mice infected with Staphylococcus aureus (S. aureus). Our results suggest that SHIP1 controls appropriate host defenses against S. aureus infections in mice.

Source: Institutional Repositories DataBase (IRDB)

Authors: Shinsuke Chida, Reietsu Itoh, Satoshi Kofuji, Satoshi Eguchi, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki

Institution: Akita University

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W569424755

FWCI:

Cites: 15

Cited by:

Related to: 10