Work

TGF-β signaling and its targeting for glioma treatment.

Year: 2015

Type: review

Abstract: Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine, secreted by a variety of cells including immune cells, tumor cells, and stromal cells. TGF-β signaling is dysregulated in cancer patients, and this aberrant signaling at least in part contributes to initiation and progression of many cancers including glioma. The dysregulated signaling components provide molecular targets for the treatment of glioma. In this article, we review TGF-β signaling and its targeting in glioma.

Source: PubMed

Authors: Jianfeng Han, Christopher A Alvarez-Breckenridge, Qi-En Wang, Jianhua Yu

Institutions: The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Massachusetts General Hospital

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Award: Elucidate and Modulate TGF-b Signaling in NK Cells for Glioma Treatment