Year: 2012
Type: article
Abstract: Historically, necrosis has been viewed as a non-regulated form of cell death.Recently studies have shown that necrosis, like apoptosis, can be a regulated form of cell death, suggesting the existence of a programmed necrotic pathway.For instance, necrotic cell death is inhibited in cells deficient for Cyclophilin D (CypD), a mitochondrial prolyl isomerase that resides in the matrix of the mitochondria.CypD is required for programmed necrosis because it regulates the mitochondrial permeability transition pore (MPTP).The MPTP is thought to span the intermembrane space of the mitochondria and to consist of both an inner and outer component on the mitochondrial membranes.The molecular identity of these two membrane components of the MPTP remains unresolved.Upon opening of the MPTP, mitochondrial swelling, loss of energy production, and initiation of necrotic cell death occurs.MPTP opening takes place in
Author: Jason Karch
Institution: University of Cincinnati
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W58654425