Novel Directions In Therapy Against Age-Related Vascular Disease
Year: 2014
Type: dissertation
Abstract: __Abstract__ \n \nGenomic instability is recognized as one of the primary mechanisms that lead to organismal \naging, and leads to progeria when developing in an accelerated pace due to defective \ngenomic maintenance systems, such as nucleotide excision repair, in humans and mouse \nmodels of progeroid syndromes. The role of genomic instability related to nuclear DNA is \ncurrently under investigation with respect to its role in cardiovascular disease, in particular \nin relation to vascular aging. In this review we highlight the first findings in this field of \nresearch that come from experiment in nucleotide excision repair-defective mouse models \nand from genetic studies. Possible mechanisms that mediate the consequences of genomic \ninstability at the local, vascular and at the systemic level, such as cell senescence, mutations, \nmitochondrial damage, and sirtuin 1 and IGF-1 decrease, are discussed and important goals \nfor future research are set.
Author: Haiyan Wu
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W58808350