Year: 2010
Type: dissertation
Study design: Observational Study
Abstract: The most frequent primary brain tumors in adults are gliomas. Since it's established that angiogenesis is strongly linked with the growth mechanism of glioma, several drugs with anti-angiogenic effects have been developed and tested as a supplementary therapy in addition to radio-and chemotherapy. New approaches using MRI have been developed to estimate non-invasively the tumoral neoangiogenesis in vivo and to study its impact on the vascularization of peritumoral tissue. The first part of this thesis was performed to evaluate the prognostic value of measuring cerebral blood volume (CBV) by perfusion MRI for the survival of patients with oligodendroglioma or mixed oligoastrocytoma. The results showed that the relative CBV measured by MRI first pass perfusion appearing as a prognostic factor for the survival of these patients. The second part of this thesis aims to estimate the basal peri-tumor perfusion by first pass technique and peri-tumor vasoreactivity by the technique of fMRI during inhalation of carbogen to assess pathophysiological mechanisms of BOLD signal changes in the vicinity of primary brain tumors. The results indicated that the alteration of basal infusion could not explain the deficit in motor activation in the primary motor cortex. The BOLD response to carbogen was the best factor to explain the asymmetry of motor activation.
Source: HAL
Author: Jiang Zhen
Language: French
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W590492266