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A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media

Year: 1995
Type: article
Abstract: A monoclonal antibody, 3B11, was raised to a novel protein, amyloid precursor-like protein 2, which did not recognize amyloid precursor protein. Multiple bands were detected in human brain fractions and cell lysate by Western blotting, indicating the presence of isoforms, 3B11 immunoreactivity was also detected in cerebrospinal fluid and conditioned medium, indicating that the protein is secreted. Immunocytochemistry revealed 3B11 immunoreactivity in sections of human brain.
DOI: 10.1042/bj3100095
Authors: M T Webster, N Groome, P T Francis, B R Pearce, F E Sherriff, G Thinakaran, K M Felsenstein, W Wasco, R E Tanzi, D M Bowen
Institutions: UCL Queen Square Institute of Neurology, Oxford Brookes University, University of Oxford, Johns Hopkins University, Johns Hopkins Medicine, Bristol-Myers Squibb (United States), Harvard University
Language: English
Subfield: Physiology
Field: Medicine
Open Access status: bronze
OpenAlex ID: W60373930
FWCI: 1.985
Cites: 22
Cited by: 33
Related to: 10