Perinatal Outcomes of Magnesium sulphate and Diazepam use in Severe Pre-eclamptic and Eclamptic Mothers, Jimma University Specialized Hospital, Southwest Ethiopia
Year: 2014
Type: article
Study design: Observational Study
Abstract: Currently the preferred anticonvulsant used to treat and prevent fits in eclampsia is magnesium sulphate. The main objective of this study was to evaluate the perinatal outcomes of magnesium sulphate and diazepam use in the management of severe pre-eclampsia and eclampsia in Jimma University Specialized Hospital. A retrospective hospital based cross-sectional comparative study was conducted using data collection format. Data was collected from the hospital delivery care register and patient chart records of all mothers who presented with the diagnosis of severe pre-eclampsia and eclampsia in two years and three months period from January, 2010 to April, 2012. Descriptive analysis such as frequency and percentage, Chi-square test, binary logistic regression and non parametric tests were analyzed by SPSS version 16.0. A P-value of <0.05 was considered statistically significant in all tests. A total data of 343 births were included in this study. Two hundred seventeen from magnesium sulphate and one hundred forty from diazepam treated mothers group, were reviewed and analyzed. There were ninety eight still births yielding a stillbirth rate of 24.5% and 35.1% for the magnesium sulphate and diazepam groups respectively. Fewer newborns in the magnesium sulphate treated group had Apgar scores less than seven than in the diazepam treated group at first and fifth minutes. A higher proportion of babies from the diazepam group were admitted to the neonatal ward than from the magnesium sulphate group (31.8% versus 18.1%). Birth outcome, first minute Apgar score and admission to the neonatal ward had a statistically significant association with the type of anticonvulsant used. Magnesium sulphate is more effective than diazepam in the management of severe pre-eclamptic and eclamptic mothers in terms of improving Apgar scores, reducing stillbirth outcome and admission to the neonatal ward. Therefore, its accessibility and wider use should be promoted.
Institution: Jimma University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Jimma University
OpenAlex ID: W60448801