Work

Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection

Year: 2011

Type: dissertation

Abstract: High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the transcription factor signal transducer and activator of transcription 3 (STAT-3), has been identified as a key signalling pathway in cardioprotection, although the end effector remains unclear.

Source: Open University of Cape Town (University of Cape Town)

Author: Damian Hacking

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Research Foundation, University of Cape Town

OpenAlex ID: W608608055

Cites: 176

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Related to: 10