Work

Immunotherapy and Radiation – A New Combined Treatment Approach for Bladder Cancer?

Year: 2015

Type: review

Abstract: Recently, immunotherapy with checkpoint inhibitors has been showing promise in clinical trials for stage IV bladder cancer. Herein, we review the literature regarding the role for radiation therapy, the role for immunotherapy, and the potential synergy of these treatments combined in bladder cancer. There is ample pre-clinical data in a number of different tumor models, coupled with a growing body of clinical evidence in melanoma and other malignancies to suggest combining radiation and immunotherapy could lead to substantial advances in treatment outcomes for bladder cancer. Yet, these data for bladder cancer remain at the pre-clinical stage, and further study is needed.

Source: Bladder Cancer

DOI: 10.3233/blc-150014

Authors: Zachary S. Buchwald, Jason A. Efstathiou

Institutions: Saint Louis University, Harvard University, Massachusetts General Hospital

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W610805448

FWCI: 0.373

Cites: 117

Cited by: 22

Related to: 10