Combined bone marrow and whole organ transplantation from the same donor.
Year: 1994
Type: article
Abstract: The recognition that after transplantation resident bone marrow-derived cells migrate out of the graft into the recipient has led to an increasing acceptance that the consequent establishment of chimerism is a seminal event in whole organ allograft acceptance, and the first step towards subsequent induction of donor-specific nonreactivity.1–6 Because the migratory interstitial cells are of hematolymphoid origin, the next logical attempt was to augment this natural phenomenon by infusing donor bone marrow cells at the time of whole organ transplantation.
The goal of this study was to induce a higher level of chimerism in unmodified recipients of liver, kidneys, heart, and pancreatic islets by perioperative infusion of unaltered bone marrow from the same donor, in an attempt to either enhance graft survival and/or decrease or ultimately eliminate the requirement for chronic nonspecific immunosuppression.
Source: PubMed
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W632208236