Sleep duration, cognitive decline, and dementia risk in older women

Year: 2015

Type: article

Abstract: INTRODUCTION: Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. METHODS: We conducted a prospective study on 7444 community-dwelling women (aged 65-80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995-2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. RESULTS: We found a statistically significant (P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. DISCUSSION: In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.

Source: Alzheimer s & Dementia

DOI: 10.1016/j.jalz.2015.03.004

Authors: Jiu‐Chiuan Chen, Mark A. Espeland, Robert L. Brunner, Laura C. Lovato, Robert B. Wallace, Xiaoyan Leng, Lawrence S. Phillips, Jennifer G. Robinson, Jane M. Kotchen, Karen C. Johnson, JoAnn E. Manson, Marcia L. Stefanick, Gloria E. Sarto, W. Jerry Mysiw

Institutions: University of Southern California, Wake Forest University Health Sciences, Wake Forest University, University of Nevada, Reno, University of Iowa, Emory University, Atlanta VA Medical Center, Medical College of Wisconsin, University of Tennessee Health Science Center, Brigham and Women's Hospital, Harvard University, Stanford Medicine, Stanford University, University of Wisconsin–Madison, The Ohio State University

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Women's Health Initiative, Wake Forest University, National Institutes of Health, U.S. Public Health Service, Society for the History of Psychology, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

OpenAlex ID: W638107684