Germline mutations of BRCA1 and BRCA2 genes - founder effects and contribution to ovarian carcinoma in Finland
Year: 2002
Type: dissertation
Abstract: 9 INTRODUCTION 11 REVIEW OF THE LITERATURE 13 1 General features of ovarian carcinoma 13 2 General features of breast carcinoma 14 3 Genes involved in carcinogenesis 14 4 Inherited predisposition to cancer 15 5 Inherited predisposition to breast and ovarian carcinoma 16 6 BRCA1 and BRCA2 genes 18 6.1 Structure and expression 18 6.2 BRCA1 and BRCA2 gene-encoded protein products and their proposed functions 18 6.3 Inherited germline mutations 20 6.3.1 Spectrum 20 6.3.2 Ethnic differences in mutation spectra 22 6.3.3 Prevalence 23 6.4 Risk of cancer in BRCA1 and BRCA2 mutation carriers 29 6.5 Prediction of presence of a BRCA1/BRCA2 germline mutation in a family 31 6.6 Characteristics of BRCA1 and BRCA2 mutation-associated breast and ovarian carcinomas 32 6.6.1 Breast carcinomas 32 6.6.2 Ovarian carcinomas 33 6.7 Prognosis of patients with BRCA1 or BRCA2 mutation-associated breast or ovarian carcinoma 34
Source: Työväentutkimus Vuosikirja
Author: Laura Sarantaus
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W641968623