Work

Distributed Sensor Particles for Remote Fluorescence Detection of Trace Analytes: UXO/CW

Year: 2001

Type: report

Abstract: This report summarizes the development of sensor particles for remote detection of trace chemical analytes over broad areas, e.g residual trinitrotoluene from buried landmines or other unexploded ordnance (UXO). We also describe the potential of the sensor particle approach for the detection of chemical warfare (CW) agents. The primary goal of this work has been the development of sensor particles that incorporate sample preconcentration, analyte molecular recognition, chemical signal amplification, and fluorescence signal transduction within a ''grain of sand''. Two approaches for particle-based chemical-to-fluorescence signal transduction are described: (1) enzyme-amplified immunoassays using biocompatible inorganic encapsulants, and (2) oxidative quenching of a unique fluorescent polymer by TNT.

DOI: 10.2172/789593

Authors: ANUP SINGH, ALOK GUPTA, ASHOK MULCHANDANI, WILFRED CHEN, RIMPLE BHATIA, JOSEPH SCHOENIGER, CAROL ASHLEY, C BRINKER, BRADLEY HANCE, RANDAL SCHMITT, MARK JOHNSON, PHILIP HARGIS, JR, ROBERT SIMONSON

Institutions: Sandia National Laboratories California, University of California, Riverside, University of New Mexico, Sandia National Laboratories

Language: English

Topic: Analytical Chemistry and Sensors

Subfield: Bioengineering

Field: Chemical Engineering

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Department of Energy, Deutsche Gesetzliche Unfallversicherung, Sandia National Laboratories

Awards: G194215011, G351415096, G7318852158, G8456466421

OpenAlex ID: W64695351

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