Systemic Cytokine and Interferon Responsiveness Patterns in HIV and HCV Mono and Co-Infections
Year: 2014
Type: article
Abstract: The role of host response-related factors in the fast progression of liver disease in individuals co-infected with HIV and HCV viruses remains poorly understood. This study compared patterns of cytokines, caspase-1 activation, endotoxin exposure in plasma as well as interferon signaling in peripheral blood mononuclear cells from HIV/HCV co-infected (HIV(+)/HCV(+)), HCV mono-infected (HIV(-)/HCV(+)), HIV mono-infected (HIV(+)/HCV(-)) female patients and HIV- and HCV-uninfected women (HIV(-)/HCV(-)) who had enrolled in the Women's Interagency HIV Study (WIHS). HIV(+)/HCV(+) women had higher plasma levels of pro-inflammatory cytokines as well as caspase-1 compared with other groups. Both HIV(+)/HCV(+) and HIV(+)/HCV(-) women had significantly higher sCD14 levels compared with other groups. Peripheral blood mononuclear cells from HCV mono-infected patients had reduced levels of phosphorylation of STAT1 compared with other groups as well as lower basal levels of expression of the IFN-stimulated genes, OAS1, ISG15, and USP18 (UBP43). Basal expression of USP18, a functional antagonist of ISG15, as well as USP18/ISG15 ratios were increased in the HIV(+)/HCV(+) group compared with HIV(-)/HCV(+) and HIV(+)/HCV(-) groups. A more pronounced systemic inflammatory profile as well as increased expression ratios of USP18 to ISG15 may contribute to the more rapid progression of liver disease in HIV(+)/HCV(+) individuals.
Authors: Rafael Fernandez-Botran, Swati Joshi-Barve, Smita Ghare, Shirish Barve, Mary Young, Michael Plankey, Jose Bordon
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, University of California, San Francisco, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1252706584, G1383752764, G1423343497, G1440661678, Clinical and Translational Science Institute, G1653728403, G1689765846, G1919789535, G2037985070, G2210861095, G2567544100, G2574405597, G2674972404, G2692709432, G2889922178, G3009646583, G3079921036, G316338625, G3212103026, G3222910550, G3264576717, G3322721267, The Connie Wofsy Women's HIV Study, Brooklyn Women's Interagency HIV Study (WIHS) V, G3658850503, G3901006228, G398667773, G4097647764, G4210511483, G4419450409, WIHS Data Management and Analysis Center (WDMAC), G4547062945, G4622231416, Southern California Women's Interagency HIV Study Consortium, G4664570284, G4804712267, G4897434353, G499585988, Chicago WIHS Consortium V (CWC), G5182092287, G5282551706, G5514441876, Washington Women's Interagency HIV/AIDS Study, Clinical and Translational Science Institute, G6295786800, G6694807131, G7195401492, G758528517, Women's Interagency HIV Study (WIHS-V), G8121648955, G826976987, G8350406629, G8355300055, G893076474, G8962527242, G8964979204, G9000034972, G9000058261, G9000073987, G9000237332, G9000338758, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, G90347297, G920507375, G925273713, G937853209, G976727283
OpenAlex ID: W65221961