Behavioral neuroendocrine studies of the influences of early adverse experiences on the development of emotional and social behaviors
Year: 2011
Type: article
Abstract: Increasing number of evidence supports the view that the early life period is a sensitive age in which adverse experiences enhance the risk of developing psychopathologies throughout life in hu mans. Maternal separation (MS) is a well-established animal model that mimics the stress of early adverse experiences. Numerous studies using this model in mice and rats have shown MS effects on emotionality, depression-like, and anxiety-related behaviors in both sexes. Furthermore, recent studies have demonstrated that the adverse effects of MS may greatly modify various social behaviors and neu roendocrine functions in adulthood. In this article, we overviewed 1) sex, species, and strain-dependent behavioral effects of MS in both non-social and social contexts, and 2) possible neuroendocrine mecha nisms of behavioral changes caused by MS. Our focus was to demonstrate how these studies in the field of behavioral neuroendocrinology might help for better understanding the effects of early life ex
Authors: Mumeko C. Tsuda, Sonoko Ogawa
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W656148352