Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
Year: 2015
Type: article
Abstract: The authors recently completed an additional sample quality control process for the RNA-sequencing (RNA-seq) data reported in the manuscript that involved matching base calling from the RNA-seq data to the associated genotyping data and clinical metadata for each subject.This process identified 55 RNA-seq data files that were not linked to the correct clinical metadata.For 41 RNA-seq data files, the relabeling occurred within Crohn disease (CD) cases.For 6 files, the relabeling resulted in a change in diagnosis from ulcerative colitis (UC) to CD, while for 6 files, the relabeling resulted in a change in diagnosis from CD to UC.One file was relabeled within the noninflammatory bowel diseases (non-IBD) control group, and for 1 file, relabeling resulted in a change from CD to non-IBD control.In addi-
DOI: 10.1172/jci79657
Authors: Yael Haberman, Timothy L. Tickle, Phillip J. Dexheimer, Mi-Ok Kim, Dora Tang, Rebekah Karns, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Melvin B. Heyman, Anne M. Griffiths, Wallace V. Crandall, David R. Mack, Susan S. Baker, Curtis Huttenhower, David J. Keljo, Jeffrey S. Hyams, Subra Kugathasan, Thomas D. Walters, Bruce Aronow, Ramnik J. Xavier, Dirk Gevers, Lee A. Denson
Institutions: Overlook Medical Center, Morristown Medical Center
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W656395023