Searching for genes predisposing to common dyslipidemias
Year: 2004
Type: dissertation
Abstract: 9 INTRODUCTION 11 REVIEW OF THE LITERATURE 12 1. OVERVIEW OF LIPOPROTEIN METABOLISM 14 1.2 HDL 14 2. Clinical and metabolic characteristics of familial low HDL-C and FCHL disorders .....15 2.1 Low HDL-cholesterol 15 2.2 Familial combined hyperlipidemia 16 2.3 The metabolic syndrome and type 2 DM 17 3. COMPLEX TRAITS AND THE ISOLATED POPULATION OF FINLAND 18 4. STRATEGIES FOR MAPPING GENES UNDERLYING COMPLEX TRAITS .........23 4.1 Human Genome Project 24 4.1.1 Comparative genomic approach 26 4.2 Qualitative and quantitative traits 26 4.3 Statistical methods for mapping complex disease genes 27 4.3.1 Parametric linkage analysis 27 4.3.2 Non-parametric linkage analysis: Allele-sharing methods 28 4.3.3 Variance component linkage analysis 29 4.3.4 Association analysis 29 4.3.5 Linkage disequilibrium (LD) analysis 30 4.3.6 Genome-wide association studies 30 4.4 Haplotype blocks and the HapMap project 30 4.5 DNA microarray 31 5. GENETICS OF LOW HDL-C AND FCHL DISORDERS 32 5.1 Candidate genes of low HDL-C 32 5.2 Candidate genes of FCHL 34 5.3 Some important candidate genes of low HDL-C and FCHL 35 5.4 Chromosomal loci identified for low HDL-C 37 5.5 Chromosomal loci identified for FCHL 38 5.6 Chromosome 1q21 region 39 AIMS OF THE PRESENT STUDY 41 MATERIALS AND METHODS 42 1. TABLE OF MATERIALS AND METHODS 42 2. SUBJECTS 43 2.1 Study sample 1: Low HDL-C families 43 2.2. Study sample 2: FCHL families 44 3. LIPID MEASUREMENTS 45
Source: Työväentutkimus Vuosikirja
Author: Heidi E. Lilja
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W657596204