Year: 2003
Type: article
Abstract: Not to correct QT, but how to, that is the question".The QT interval is a reflection of the action potential in the cardiac cells.Homogenous or heterogenous changes in the action potential duration lead to alteration of QT interval (in addition to morphological changes of T & U waves) 1 .Such changes can be due to change in heart rate & autonomic tone.They can also be markers of abnormal repolarization, depolarization or both as a result of electrolyte disturbances, cardiac diseases, drugs and congenital long QT syndromes 2 .Repolarization disorders are responsible for life threatening arrhythmias like torsades de pointes 2 .The purpose of heart rate correction is to obtain a standardized value that would have been measured in the same subject if the heart rate was 60 beats per minute (QTc).Thus this QTc value will now become independent of the heart rate and measure replarization changes.It will thus be a surrogate marker of the risk of torsade de pointes.The concept of QTc appeared in 1920, when Bazett introduced his square root formula 3 .This formula obtained from data on 39 young men has been questioned because it overcorrects QT at fast heart rate and undercorrects at low heart rate (4).Thus at slow heart rate, which is one of the predisposing factors of torsade initiation, Bazett correction can easily mask substantial QT prolongation by under correcting.This can hide the proarrhythmic toxicity of drugs slowing heart rate.An alternative, cube root correction of Fridericia, corrects better than Bazett but again is not reliable at fast heart rates.Compared to these non linear correction formulae, linear regression correction obtained from large population data, like the Framingham heart study linear correction are still better 4 .However the QT does not adapt to changes in heart rate immediately.It takes more than 2 minutes for the QT to adapt (QT/RR hysteresis).Hence correction needs to be done at steady heart rates 1 .The concept of heart rate correction ignores the dynamicity of QT/RR relationship 6 .The QT interval is also under autonomic control.Therefore different modes of heart rate changes, e.g.fast heart rate due to parasympathetic withdrawal versus sympathetic overactivity, lead to different direct and reflex effects on QT prolongation.Hence the standard QTc correction formula will not be representative of the actual repolarization milleu.Ideally each individual should have his own correction derived from multiple ECGs at different heart rates and conditions to get the ideal correction constant.Since this is not feasible a compromise can be made by using formula which have been developed and validated in a large population based Indian Pacing and Electrophysiology Journal ( ISSN 0972-6292), 3(4): 185-186 (2003) Yash Lokhandwala & Toal SC, "The fallacies of QT correction"
Source: PubMed Central
Authors: Yash Lokhandwala, S C Toal
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W66366648