Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential.
Year: 2015
Type: article
Abstract: Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins or genomic damage, are poorly understood. Decades of research provide compelling evidence implicating metal overload in neurological diseases and stroke. However, the utility of metal toxicity as a therapeutic target is controversial, possibly due to a lack of comprehensive understanding of metal dyshomeostasis-mediated neuronal pathology. In this article, we discuss the current understanding of metal toxicity and the challenges associated with metal-targeted therapies.
Source: PubMed
DOI: 10.14437/nrtoa-1-107
Institutions: Houston Methodist, Cornell University, Weill Cornell Medicine, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, City of Knowledge, Acharya Nagarjuna University, The University of Texas Medical Branch at Galveston, Michael E. DeBakey VA Medical Center, Baylor College of Medicine
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
Awards: G1026912451, G2973076041, G750514105
OpenAlex ID: W66618813