Work

Histone modifications and cancer: biomarkers of prognosis?

Year: 2012

Type: article

Abstract: Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-translational modifications of histones, in particular, are known to play important roles gene expression alterations in cancer development and progression. Given their key involvement in the various stages of carcinogenesis, histone modifications are also being explored as potential biomarkers of disease progression and prognosis. This review will therefore discuss the role of histone modifications in cancer biology and will explore their prognostic potential.

Source: PubMed

Authors: Yana Chervona, Max Costa

Institution: New York University

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Environmental Health Sciences

Awards: Carcinogenic Metals And Their Interactions With Other Toxicants, Carcinogenesis of Nickel and Epigenetic Control, Research in Environmental Health Sciences, Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis