Work

Regulation of Ras signal transduction during T cell development and activation.

Year: 2012

Type: article

Abstract: T cell receptor-induced activation of the Ras signaling pathway is essential for T cell development, proliferation and differentiation. Given the central role of Ras in T cell biology its activation must be tightly regulated. However, precisely how Ras activation is controlled in T cells is not completely understood. In this review, we provide a summary of the known factors and mechanisms involved in positive and negative regulation of Ras activation in the T cell lineage.

Source: PubMed Central

Authors: Philip E Lapinski, Philip D King

Institution: University of Michigan

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: RASA1-mediated control of lymphatic vessel growth and function, Control of T cell activation by the TSAd adapter protein