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Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid

Year: 2025

Type: article

Abstract: As a new type of anti-tumor therapy, immune checkpoint inhibitor (ICI) can effectively improve the survival rate of tumor patients, but also bring a series of adverse reactions. Among these, immune-related cutaneous adverse events are prevalent. There is a relatively low incidence of bullous pemphigoid (BP) induced by ICI. However, this adverse event may not only negatively impact patient quality of life of patient, but also lead to treatment interruptions or discontinuations. This paper reviews the pathogenesis, prevalence, clinical manifestations, management methods of BP induced by ICI and its effect on tumor immunotherapy.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.12025/j.issn.1008-6358.2025.20241038

Authors: Yi SUN, Ji YANG

Institutions: Fudan University, Zhongshan Hospital

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6884748761