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The functional characteristics of GPR120 and its mechanism in preventing atherosclerosis

Year: 2025

Type: article

Abstract: Free fatty acids are important substances for regulating energy metabolism in the body and mainly exert their functions by binding to G protein-coupled receptors（GPRs）on the cell membrane. GPR120 is the receptor for medium and long-chain free fatty acids in mammals. Studies have found that the activation of GPR120 on endothelial cells，vascular smooth muscle cells，and monocytes/macrophages can reduce monocyte adhesion，promote cholesterol efflux from foam cells，regulate the migration and differentiation of macrophages，and exert anti-inflammatory and antioxidant functions，potentially resisting atherosclerosis. This article reviews the molecular structure，tissue distribution，ligand types，signal transduction pathways of GPR120，and its research progress in anti-atherosclerotic diseases，aiming to reveal the molecular mechanism of GPR120 in resisting atherosclerosis and its potential value as a therapeutic target.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.12464/j.issn.0253-9802.2024-0500

Author: XIAO Jiahai, CHEN Gengji, ZHANG Pengfei, WU Tianyu, CHEN Xiaojia, ZHANG Zhizhen

Institutions: Guangdong Medical College, The First Affiliated Hospital, Sun Yat-sen University

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6884751063

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