Work

Research progress on cancer-associated fibroblasts in malignant tumors

Year: 2025

Type: article

Abstract: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) and play an essential role in the development of tumors. It is suggested that CAFs influence tumor cell proliferation, invasion and migration as well as regulate tumor cell resistance to chemotherapeutic agents through the secretion of cytokines, chemokines, growth factors and extracellular matrix proteins. And they also enhance the immune escape ability of tumors by interacting with tumor-associated immune cells. This article comprehensively expounds how the biomarkers and subtypes of CAFs can promote the development of malignant tumors by affecting the immune escape of tumor cells and TME, and discusses the mechanism and potential treatment strategies of CAFs in malignant tumors.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.12173/j.issn.1004-5511.202410036

Authors: DU Yuxin, WU Rihan, LIU Caixia

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6884759147

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