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The 28-day oral toxicity of the extract of Silybum marianum in rats

Year: 2024

Type: article

Abstract: ObjectiveThis study aimed to assess the 28-day oral toxicity of Sihbum manalttlm extract in rats.MethodsSD rats were administered S. manalttlm extract, and effects on body weight, organ coefficients, biochemical indicators, blood routine and hemagglutination indicators, and liver pathology were evaluated to determine safety.ResultsS. manalttlm extract showed no adverse effects on body weight, organ coefficients, biochemical indicators, blood routine and coagulation indicators, or liver pathology. Additionally, S. manalttlm extract appeared to positively influence pathways related to plasma amino acid metabolism, liver riboflavin metabolism, carbohydrate metabolism, and sphingolipid metabolism, contributing to overall health benefits in rats.ConclusionS. manalttlm extract was deemed safe Under the dosage and conditions of this study.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.13652/j.spjx.1003.5788.2024.80536

Authors: JI Hainan, ZHAO Chan, LIN Zijun, TONG Na, CHEN Bowen, ZHOU Shimeng, LIU Mingchang, SHEN Guolin, ZHANG Mengling

Institutions: Chinese Academy of Inspection and Quarantine, State Administration for Market Regulation

Language: English

Topic: Silymarin and Mushroom Poisoning

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6885396798

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