Work

Research progress of lncRNA UCA1 in oral squamous cell carcinoma

Year: 2025

Type: article

Abstract: Oral squamous cell carcinoma(OSCC) is the most prevalent malignant tumor in the head and neck region, with a relatively high incidence and mortality rate. Long non-coding RNA(lncRNA) is an important class of non-coding RNA molecules that play a crucial role in the occurrence and progression of OSCC. Urothelial carcinoma associated 1(UCA1) is highly expressed in OSCC, where it regulates the biological behavior of tumor cells through miRNA sponge activity and activation of downstream signaling pathways. This article reviews the mechanisms of action of UCA1 in OSCC and its research progress in areas such as tumor proliferation, invasion, metastasis, drug resistance, diagnosis, treatment and prognosis. This is expected to provide a theoretical foundation for the potential clinical applications of UCA1 in OSCC.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.13591/j.cnki.kqyx.2025.04.015

Author: CHEN Yue, SUN Xueqian, CHEN Minmin

Institution: Xuzhou Medical College

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6885422010

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